Ontology highlight
ABSTRACT:
SUBMITTER: Borkin D
PROVIDER: S-EPMC4415852 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20150326 4
Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention. Here we report the development of highly potent and orally bioavailable small-molecule inhibitors of the menin-MLL interaction, MI-463 and MI-503, and show their profound effects in MLL leukemia cells and substantial survival benefit in mou ...[more]