Randomized trial of peanut consumption in infants at risk for peanut allergy.

ABSTRACT:

Background

The prevalence of peanut allergy among children in Western countries has doubled in the past 10 years, and peanut allergy is becoming apparent in Africa and Asia. We evaluated strategies of peanut consumption and avoidance to determine which strategy is most effective in preventing the development of peanut allergy in infants at high risk for the allergy.

Methods

We randomly assigned 640 infants with severe eczema, egg allergy, or both to consume or avoid peanuts until 60 months of age. Participants, who were at least 4 months but younger than 11 months of age at randomization, were assigned to separate study cohorts on the basis of preexisting sensitivity to peanut extract, which was determined with the use of a skin-prick test--one consisting of participants wit

SUBMITTER: Du Toit G 

PROVIDER: S-EPMC4416404 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature