Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors.

ABSTRACT: A series of imidazolepyridine derivatives were designed and synthesized according to the established docking studies. The imidazopyridine derivatives were found to have good potency and physical-chemical properties. Several highly potent compounds such as 8ji, 8jl, and 8jm were identified with single nanomolar activities. The most potent compound 8jm showed an IC50 of 3 nM, lower microsome clearance and no CYP inhibition. The profile of 8jm appeared to be superior to BMS433771, and supported further optimization.

SUBMITTER: Feng S 

PROVIDER: S-EPMC4416423 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature