An Eye on Brain Integrity: Acute Optic Neuritis Affects Resting State Functional Connectivity.

ABSTRACT:

Purpose

Currently, the ability for imaging to capture brain adaptations to injury that occurs in multiple sclerosis (MS) is limited. In particular, how the brain initially contends with the earliest clinical manifestations of white matter injury has yet to be defined. The purpose of this study was to determine the impact of acute optic neuritis (ON) on resting state functional connectivity magnetic resonance imaging (rs-fcMRI).

Methods

Fifteen patients with a clinically isolated syndrome of acute ON were evaluated at an academic center in a prospective study. Subjects were assessed with structural and functional vision measures, including optical coherence tomography (OCT), high- and low-contrast letter acuity testing, and visual fields and quality-of-life measures (VFQ-25).

SUBMITTER: Wu GF 

PROVIDER: S-EPMC4416526 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature