Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy.

ABSTRACT: Transitions into primary generalized epileptic seizures occur abruptly and synchronously across the brain. Their potential triggers remain unknown. We used optogenetics to causally test the hypothesis that rhythmic population bursting of excitatory neurons in a local neocortical region can rapidly trigger absence seizures. Most previous studies have been purely correlational, and it remains unclear whether epileptiform events induced by rhythmic stimulation (e.g., sensory/electrical) mimic actual spontaneous seizures, especially regarding their spatiotemporal dynamics. In this study, we used a novel combination of intracortical optogenetic stimulation and microelectrode array recordings in freely moving WAG/Rij rats, a model of absence epilepsy with a cortical focus in the somatosensory co

SUBMITTER: Wagner FB 

PROVIDER: S-EPMC4416582 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature