Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension.

ABSTRACT:

Purpose

The pathophysiology of ocular hypertension (OH) leading to primary open-angle glaucoma shares many features with a secondary form of OH caused by treatment with glucocorticoids, but also exhibits distinct differences. In this study, a pharmacogenomics approach was taken to discover candidate genes for this disorder.

Methods

A genome-wide association study was performed, followed by an independent candidate gene study, using a cohort enrolled from patients treated with off-label intravitreal triamcinolone, and handling change in IOP as a quantitative trait.

Results

An intergenic quantitative trait locus (QTL) was identified at chromosome 6p21.33 near the 5' end of HCG22 that attained the accepted statistical threshold for genome-level significance. The HCG22 tr

SUBMITTER: Jeong S 

PROVIDER: S-EPMC4416661 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature