Short LOV Proteins in Methylocystis Reveal Insight into LOV Domain Photocycle Mechanisms.

ABSTRACT: Light Oxygen Voltage (LOV) proteins are widely used in optogenetic devices, however universal signal transduction pathways and photocycle mechanisms remain elusive. In particular, short-LOV (sLOV) proteins have been discovered in bacteria and fungi, containing only the photoresponsive LOV element without any obvious signal transduction domains. These sLOV proteins may be ideal models for LOV domain function due to their ease of study as full-length proteins. Unfortunately, characterization of such proteins remains limited to select systems. Herein, we identify a family of bacterial sLOV proteins present in Methylocystis. Sequence analysis of Methylocystis LOV proteins (McLOV) demonstrates conservation with sLOV proteins from fungal systems that employ competitive dimerization as a signalin

SUBMITTER: El-Arab KK 

PROVIDER: S-EPMC4416707 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature