Quantification of Interactions between Dynamic Cellular Network Functionalities by Cascaded Layering.

ABSTRACT: Large, naturally evolved biomolecular networks typically fulfil multiple functions. When modelling or redesigning such systems, functional subsystems are often analysed independently first, before subsequent integration into larger-scale computational models. In the design and analysis process, it is therefore important to quantitatively analyse and predict the dynamics of the interactions between integrated subsystems; in particular, how the incremental effect of integrating a subsystem into a network depends on the existing dynamics of that network. In this paper we present a framework for simulating the contribution of any given functional subsystem when integrated together with one or more other subsystems. This is achieved through a cascaded layering of a network into functional subsy

SUBMITTER: Prescott TP 

PROVIDER: S-EPMC4416712 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature