Role of Mechanical Cues in Cell Differentiation and Proliferation: A 3D Numerical Model.

ABSTRACT: Cell differentiation, proliferation and migration are essential processes in tissue regeneration. Experimental evidence confirms that cell differentiation or proliferation can be regulated according to the extracellular matrix stiffness. For instance, mesenchymal stem cells (MSCs) can differentiate to neuroblast, chondrocyte or osteoblast within matrices mimicking the stiffness of their native substrate. However, the precise mechanisms by which the substrate stiffness governs cell differentiation or proliferation are not well known. Therefore, a mechano-sensing computational model is here developed to elucidate how substrate stiffness regulates cell differentiation and/or proliferation during cell migration. In agreement with experimental observations, it is assumed that internal deformati

SUBMITTER: Mousavi SJ 

PROVIDER: S-EPMC4416758 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature