Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression.

ABSTRACT: Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. To get insights into the dynamics of cell differentiation and malignant transformation we have compared the DNA methylation profiles along the mouse small intestine crypt and early stages of tumorigenesis. Genome-scale analysis of DNA methylation together with microarray gene expression have been applied to compare intestinal crypt stem cells (EphB2high), differentiated cells (EphB2negative), ApcMin/+ adenomas and the corresponding non-tumor adjacent tissue, together with small and large intestine samples and the

SUBMITTER: Forn M 

PROVIDER: S-EPMC4416816 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature