Systematic Review: Representativeness of Participants in RCTs of Acetylcholinesterase Inhibitors.

ABSTRACT:

Objective

To determine whether there are differences in age and sex distribution and presence of comorbidities between participants included in randomized controlled trials of acetylcholinesterase inhibitors and nationwide cohort of persons with Alzheimer's disease.

Methods

PubMed, Scopus and Cochrane Library databases were searched for original articles from their inception to January 4, 2015. Double-blind randomized controlled trials with donepezil, rivastigmine or galantamine compared to placebo in participants with Alzheimer's disease were included. Data from a nationwide cohort of persons with clinically verified diagnoses of Alzheimer's disease was defined as a reference population.

Results

128 full-text articles were assessed for eligibility, 31 of them fulfill

SUBMITTER: Leinonen A 

PROVIDER: S-EPMC4416896 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature