Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer.

ABSTRACT:

Background and objective

Inhibitors of apoptosis proteins (IAPs) have been well investigated in human cancers, where they are frequently overexpressed and associated with poor prognosis. Here we explored the role of baculoviral IAP repeat containing 6 (BIRC6), a member of IAPs, in human colorectal cancer (CRC).

Methods

We used Western blotting and immunohistochemistry to examine BIRC6 expression in 7 CRC cell lines and 126 CRC clinical samples. We determined the biological significance of BIRC6 in CRC cell lines by a lentivirus-mediated silencing method.

Results

We reported that BIRC6 was overexpressed in CRC cell lines and clinical CRC tissues. BIRC6 overexpression was correlated with tumor size and invasion depth of CRC. BIRC6 overexpression is associated with worse

SUBMITTER: Hu T 

PROVIDER: S-EPMC4416929 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature