TMREC: A Database of Transcription Factor and MiRNA Regulatory Cascades in Human Diseases.

ABSTRACT: Over the past decades, studies have reported that the combinatorial regulation of transcription factors (TFs) and microRNAs (miRNAs) is essential for the appropriate execution of biological events and developmental processes. Dysregulations of these regulators often cause diseases. However, there are no available resources on the regulatory cascades of TFs and miRNAs in the context of human diseases. To fulfill this vacancy, we established the TMREC database in this study. First, we integrated curated transcriptional and post-transcriptional regulations to construct the TF and miRNA regulatory network. Next, we identified all linear paths using the Breadth First Search traversal method. Finally, we used known disease-related genes and miRNAs to measure the strength of association between c

SUBMITTER: Wang S 

PROVIDER: S-EPMC4416930 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature