Biomarkers related to severe hypoglycaemia and lack of good glycaemic control in ACCORD.

ABSTRACT:

Aims/hypothesis

In patients with diabetes, intensive glycaemic control reduces microvascular complications. However, severe hypoglycaemia frequently complicates intensive glycaemic control. Blood biomarkers that predict successful intensification of glycaemic control in patients with type 2 diabetes without the development of severe hypoglycaemia would advance patient care. In patients who received intensive treatment for type 2 diabetes from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, we hypothesised that insulin deficiency and islet autoantibodies would be associated with severe hypoglycaemia and failure to achieve near-normal glycaemia (HbA1c <6.0% [42 mmol/mol]).

Methods

A nested case-control design was used. Cases (n = 326) were defined as part

SUBMITTER: Chow LS 

PROVIDER: S-EPMC4416999 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature