Modeling the relationship of epigenetic modifications to transcription factor binding.

ABSTRACT: Transcription factors (TFs) and epigenetic modifications play crucial roles in the regulation of gene expression, and correlations between the two types of factors have been discovered. However, methods for quantitatively studying the correlations remain limited. Here, we present a computational approach to systematically investigating how epigenetic changes in chromatin architectures or DNA sequences relate to TF binding. We implemented statistical analyses to illustrate that epigenetic modifications are predictive of TF binding affinities, without the need of sequence information. Intriguingly, by considering genome locations relative to transcription start sites (TSSs) or enhancer midpoints, our analyses show that different locations display various relationship patterns. For instance,

SUBMITTER: Liu L 

PROVIDER: S-EPMC4417166 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature