Admixture mapping of coronary artery calcification in African Americans from the NHLBI family heart study.

ABSTRACT:

Background

Coronary artery calcification (CAC) is an imaging biomarker of coronary atherosclerosis. In European Americans, genome-wide association studies (GWAS) have identified several regions associated with coronary artery disease. However, few large studies have been conducted in African Americans. The largest meta-analysis of CAC in African Americans failed to identify genome-wide significant variants despite being powered to detect effects comparable to effects identified in European Americans. Because CAC is different in prevalence and severity in African Americans and European Americans, admixture mapping is a useful approach to identify loci missed by GWAS.

Results

We applied admixture mapping to the African American cohort of the Family Heart Study and identified o

SUBMITTER: Gomez F 

PROVIDER: S-EPMC4417236 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature