Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.

ABSTRACT:

Background

Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineating patients with polyps and benign adenomas from normal and cancer patient groups.

Methods

The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues.

Results

High levels of circulating miR-34a and low miR-150

SUBMITTER: Aherne ST 

PROVIDER: S-EPMC4417244 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature