COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data.

ABSTRACT:

Background

Complex malaria infections are defined as those containing more than one genetically distinct lineage of Plasmodium parasite. Complexity of infection (COI) is a useful parameter to estimate from patient blood samples because it is associated with clinical outcome, epidemiology and disease transmission rate. This manuscript describes a method for estimating COI using likelihood, called COIL, from a panel of bi-allelic genotyping assays.

Methods

COIL assumes that distinct parasite lineages in complex infections are unrelated and that genotyped loci do not exhibit significant linkage disequilibrium. Using the population minor allele frequency (MAF) of the genotyped loci, COIL uses the binomial distribution to estimate the likelihood of a COI level given the prevalenc

SUBMITTER: Galinsky K 

PROVIDER: S-EPMC4417311 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature