Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.

ABSTRACT:

Background

Mammographic density (MD) is a strong breast cancer risk factor. We previously reported associations of percent mammographic density (PMD) with larger and node-positive tumors across all ages, and estrogen receptor (ER)-negative status among women ages <55 years. To provide insight into these associations, we examined the components of PMD [dense area (DA) and nondense area (NDA)] with breast cancer subtypes.

Methods

Data were pooled from six studies including 4,095 breast cancers and 8,558 controls. DA and NDA were assessed from digitized film-screen mammograms and standardized across studies. Breast cancer odds by density phenotypes and age according to histopathologic characteristics and receptor status were calculated using polytomous logistic regression.

R

SUBMITTER: Bertrand KA 

PROVIDER: S-EPMC4417380 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature