Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women.

ABSTRACT:

Objective

To examine associations between environmental exposure to perfluoroalkyl substances (PFASs) and ovarian hormone concentrations in naturally cycling women.

Design

E2 and P were measured in saliva samples collected daily for a single menstrual cycle and concentrations of PFASs (including perfluoroctane sulfonate [PFOS] and perfluoroctanoic acid) were measured in serum samples collected during the same cycle.

Setting

Not applicable.

Patient(s)

A total of 178 healthy, naturally cycling women, aged 25-35 years.

Intervention(s)

None.

Main outcome measure(s)

Mean follicular E2 (cycle days -7 to -1, where 0 is the day of ovulation); mean luteal P (cycle days +2 to 10).

Result(s)

Among nulliparous, but not parous women, PFOS concentrations

SUBMITTER: Barrett ES 

PROVIDER: S-EPMC4417395 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature