Circulating microRNAs as potential biomarkers for endometriosis.

ABSTRACT:

Objective

To evaluate whether microRNAs (miRNAs) associated with endometriosis are detectable in the circulation and could serve as potential noninvasive biomarkers for endometriosis.

Design

Case-control study.

Setting

University hospital.

Patient(s)

Twenty-four women with endometriosis and 24 women without the disease (controls).

Intervention(s)

Serum samples collected from women undergoing laparoscopy for endometriosis and other benign gynecologic disease.

Main outcome measure(s)

Total RNA extracted from serum and quantitative reverse-transcription polymerase chain reaction to determine levels of miRNA let-7a-f and miR-135a,b.

Result(s)

The levels of circulating let-7b and miR-135a were statistically significantly decreased in women with

SUBMITTER: Cho S 

PROVIDER: S-EPMC4417410 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature