Molecular characterization of hepatitis A virus strains in a tertiary care health set up in north western India.

ABSTRACT:

Background & objectives

Hepatitis A virus usually causes acute viral hepatitis (AVH) in the paediatric age group with a recent shift in age distribution and disease manifestations like acute liver failure (ALF). This has been attributed to mutations in 5'non-translated region (5'NTR) which affects the viral multiplication. The present study was aimed to carry out the molecular detection and phylogenetic analysis of hepatitis A virus strains circulating in north western India.

Methods

Serum samples from in patients and those attending out patient department of Pediatric Gastroenterology in a tertiary care hospital in north India during 2007-2011 with clinically suspected AVH were tested for anti-hepatitis A virus (HAV) IgM antibodies. Acute phase serum samples were subjected

SUBMITTER: Singh MP 

PROVIDER: S-EPMC4418158 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature