Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier.

ABSTRACT:

Background and purpose

The blood-brain barrier (BBB) is a selectively permeable cerebrovascular endothelial barrier that maintains homeostasis between the periphery and the central nervous system. BBB disruption is a consequence of ischemic stroke and BBB permeability can be altered by infection/inflammation, but the complex cellular and molecular changes that result in this BBB alteration need to be elucidated to determine mechanisms.

Methods

Infection mimic (lipopolysaccharide) challenge on infarct volume, BBB permeability, infiltrated neutrophils, and functional outcomes after murine transient middle cerebral artery occlusion in vivo; mitochondrial evaluation of cerebrovascular endothelial cells challenged by lipopolysaccharide in vitro; pharmacological inhibition of mito

SUBMITTER: Doll DN 

PROVIDER: S-EPMC4418219 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature