Effect of exclusive enteral nutrition on the microbiota of children with newly diagnosed Crohn's disease.

ABSTRACT:

Objectives

Exclusive enteral nutrition (EEN) is commonly used to treat pediatric Crohn's disease (CD). Meta-analysis of pediatric studies that have compared the effect of EEN with other treatments have shown that EEN induces remission in up to 80-85% of patients. We aimed to gain a comprehensive understanding of the effect of EEN on the microbiota of CD patients.

Methods

We used 16S rRNA gene and whole-genome high throughout sequencing to determine changes in the fecal microbiota of five CD children, before, during, and after EEN therapy and compared this with five healthy controls.

Results

The microbial diversity observed in CD patients tended to be lower than that in controls (CD: 2.25±0.24, controls: 2.75±0.14, P=0.11). In all CD patients, dysbiosis was observed pr

SUBMITTER: Kaakoush NO 

PROVIDER: S-EPMC4418409 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature