Late-onset schizophrenia: do recent studies support categorizing LOS as a subtype of schizophrenia?

ABSTRACT:

Purpose or review

To review recent literature about late-onset schizophrenia (LOS): schizophrenia with onset between ages 40 and 60 years. New findings are presented in the context of the previous literature.

Recent findings

Newer studies continue to suggest that early-onset schizophrenia (EOS) and LOS share fundamental clinical features (i.e., positive symptoms, negative symptoms, functional deficits). One larger recent study confirmed earlier findings that LOS differs from EOS in several important ways, including predominance of women, lower severity of positive symptoms, and lower average antipsychotic dose requirement. However, this study did not find LOS patients were more likely to have the paranoid subtype or to have less severe negative symptoms compared with EOS pat

SUBMITTER: Maglione JE 

PROVIDER: S-EPMC4418466 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature