Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.

ABSTRACT:

Background

Matrix metalloproteinases (MMPs) are a family of host-derived proteinases reported to mediate multiple functions associated with periodontal breakdown and inflammation. High MMP levels in African-American children with localized aggressive periodontitis (LAgP) have been reported previously by the present authors. However, little is known about MMP reductions in gingival crevicular fluid (GCF) after therapy. This study aims to evaluate MMP levels in the GCF after treatment of LAgP and to correlate these levels with clinical response.

Methods

GCF samples were collected from 29 African-American individuals diagnosed with LAgP. GCF was collected from one diseased site (probing depth [PD] >4 mm, bleeding on probing [BOP], and clinical attachment level ≥ 2 mm) and one h

SUBMITTER: Goncalves PF 

PROVIDER: S-EPMC4418528 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature