Kinetic Estimation of GFR Improves Prediction of Dialysis and Recovery after Kidney Transplantation.

ABSTRACT:

Background

The early prediction of delayed graft function (DGF) would facilitate patient management after kidney transplantation.

Methods

In a single-centre retrospective analysis, we investigated kinetic estimated GFR under non-steady-state conditions, KeGFR, in prediction of DGF. KeGFR(sCr) was calculated at 4h, 8h and 12h in 56 recipients of deceased donor kidneys from initial serum creatinine (sCr) concentrations, estimated creatinine production rate, volume of distribution, and the difference between consecutive sCr values. The utility of KeGFR(sCr) for DGF prediction was compared with, sCr, plasma cystatin C (pCysC), and KeGFR(pCysC) similarly derived from pCysC concentrations.

Results

At 4h, the KeGFR(sCr) area under the receiver operator characteristic curve (

SUBMITTER: Pianta TJ 

PROVIDER: S-EPMC4418565 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature