Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20.

ABSTRACT:

Objective

Our aim is to map chromosomal regions that harbor loci that increase susceptibility to bipolar disorder.

Methods

We analyzed 644 bipolar families ascertained by the National Institute of Mental Health Human Genetics Initiative for bipolar disorder. The families have been genotyped with microsatellite loci spaced every approximately 10 cM or less across the genome. Earlier analyses of these pedigrees have been limited to nonparametric (model-free) methods and thus, information from unaffected subjects with genotypes was not considered. In this study, we used parametric analyses assuming dominant and recessive transmission and specifying a maximum penetrance of 70%, so that information from unaffecteds could be weighed in the linkage analyses. As in previous linkage

SUBMITTER: Ross J 

PROVIDER: S-EPMC4418612 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature