Antipsychotic-induced changes in blood levels of leptin in schizophrenia: a meta-analysis.

ABSTRACT:

Objectives

Weight gain is a major side effect of antipsychotics (APs), which contributes to poor treatment adherence and significant morbidity. The mechanisms involved in AP-induced weight gain are incompletely understood. Recently, it has been proposed that changes in leptin, an cadipocyte-derived hormone exerting anorexigenic effects, may be involved in AP-induced weight gain. Thus far, studies on leptin changes during AP treatment have produced inconsistent results, prompting our group to perform a meta-analysis.

Method

A search of the literature was performed using PubMed and Embase. Studies were included only if reporting peripheral levels of leptin before and after AP treatment in schizophrenia. Effect size estimates were calculated with Hedges g and were aggregated us

SUBMITTER: Potvin S 

PROVIDER: S-EPMC4418620 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature