Increased extracellular volume and altered mechanics are associated with LVH in hypertensive heart disease, not hypertension alone.

ABSTRACT:

Objectives

The goal of this study was to assess the relationship among extracellular volume (ECV), native T1, and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH), hypertensive patients without LVH (HTN non-LVH), and normotensive controls.

Background

Diffuse myocardial fibrosis in HTN LVH patients, as reflected by increased ECV and native T1, may be an underlying mechanism contributing to increased cardiovascular risk compared with HTN non-LVH subjects and controls. Furthermore, increased diffuse fibrosis in HTN LVH subjects may be associated with reduced peak systolic and early diastolic strain rate compared with the other 2 groups.

Methods

T1 mapping was performed in 20 HTN LVH (mean age, 55 ± 11 years), 23 HTN non-LVH (mean age,

SUBMITTER: Kuruvilla S 

PROVIDER: S-EPMC4418794 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature