A multi-scale PDMS fabrication strategy to bridge the size mismatch between integrated circuits and microfluidics.

ABSTRACT: In recent years there has been great progress harnessing the small-feature size and programmability of integrated circuits (ICs) for biological applications, by building microfluidics directly on top of ICs. However, a major hurdle to the further development of this technology is the inherent size-mismatch between ICs (~mm) and microfluidic chips (~cm). Increasing the area of the ICs to match the size of the microfluidic chip, as has often been done in previous studies, leads to a waste of valuable space on the IC and an increase in fabrication cost (>100×). To address this challenge, we have developed a three dimensional PDMS chip that can straddle multiple length scales of hybrid IC/microfluidic chips. This approach allows millimeter-scale ICs, with no post-processing, to be integrated i

SUBMITTER: Muluneh M 

PROVIDER: S-EPMC4418800 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature