Consensus comparative analysis of human embryonic stem cell-derived cardiomyocytes.

ABSTRACT: Global transcriptional analyses have been performed with human embryonic stem cells (hESC) derived cardiomyocytes (CMs) to identify molecules and pathways important for human CM differentiation, but variations in culture and profiling conditions have led to greatly divergent results among different studies. Consensus investigation to identify genes and gene sets enriched in multiple studies is important for revealing differential gene expression intrinsic to human CM differentiation independent of the above variables, but reliable methods of conducting such comparison are lacking. We examined differential gene expression between hESC and hESC-CMs from multiple microarray studies. For single gene analysis, we identified genes that were expressed at increased levels in hESC-CMs in seven data

SUBMITTER: Zhang S 

PROVIDER: S-EPMC4418815 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature