A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia.

ABSTRACT: Prostate cancer is one of the leading causes of mortality among aging males. There is an unmet requirement of clinically useful biomarkers for early detection of prostate cancer to reduce the liabilities of overtreatment and accompanying morbidity. The present population-based study investigates the factors disrupting expression of multiple functionally related genes of DNA mismatch repair pathway in prostate cancer patients to identify molecular attributes distinguishing adenocarcinoma from benign hyperplasia of prostate. Gene expression was compared between tissue samples from prostate cancer and benign prostatic hyperplasia using real-time-PCR, western blot and immunohistochemistry. Assessment of genotypes of seven single-nucleotide-polymorphisms of three MMR genes was conducted using P

SUBMITTER: Basu S 

PROVIDER: S-EPMC4418837 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature