Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis.

ABSTRACT:

Objectives

Although myeloid-derived suppressor cells (MDSCs) have been linked to T cell tolerance, their role in autoimmune rheumatoid arthritis (RA) remains elusive. Here we investigate the potential association of MDSCs with the disease pathogenesis using a preclinical model of RA and specimen collected from patients with RA.

Methods

The frequency of MDSCs in blood, lymphoid tissues, inflamed paws or synovial fluid and their association with disease severity, tissue inflammation and the levels of pathogenic T helper (Th) 17 cells were examined in arthritic mice or in patients with RA (n=35) and osteoarthritis (n=15). The MDSCs in arthritic mice were also characterised for their phenotype, inflammation status, T cell suppressive activity and their capacity of pro-Th17 cell

SUBMITTER: Guo C 

PROVIDER: S-EPMC4418961 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature