Complement involvement in kidney diseases: From physiopathology to therapeutical targeting.

ABSTRACT: Complement cascade is involved in several renal diseases and in renal transplantation. The different components of the complement cascade might represent an optimal target for innovative therapies. In the first section of the paper the authors review the physiopathology of complement involvement in renal diseases and transplantation. In some cases this led to a reclassification of renal diseases moving from a histopathological to a physiopathological classification. The principal issues afforded are: renal diseases with complement over activation, renal diseases with complement dysregulation, progression of renal diseases and renal transplantation. In the second section the authors discuss the several complement components that could represent a therapeutic target. Even if only the anti C5

SUBMITTER: Salvadori M 

PROVIDER: S-EPMC4419127 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature