Donor caveolin 1 (CAV1) genetic polymorphism influences graft function after renal transplantation.

ABSTRACT:

Background

Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the discovery of susceptibility genes, much remains to be learned about the functions of disease-associated genetic variants. Recently, Moore and co-workers identified, in the donor genome, an association between a common genetic variant (rs4730751) in the gene encoding caveolin-1 (CAV1), a major structural component of caveolae, and long-term allograft survival.

Methods

Four hundred seventy-five renal recipients consecutively transplanted were included in this study. Donor genomic DNA was extracted and used to genotype CAV1 rs4730751 Single Nucleotide Polymorphism.

SUBMITTER: Van der Hauwaert C 

PROVIDER: S-EPMC4419392 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature