Resistin - 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus.

ABSTRACT:

Background

Resistin is a circulating adipokine with insulin-antagonizing effects. The aim of this study was to investigate the relationship between the single nucleotide polymorphism (SNP) -420C > G in the resistin gene with serum resistin levels, insulin resistance, and risk of gestational diabetes (GDM) in Iranian population.

Method

75 GDM patients and 70 healthy pregnant women were enrolled in this study. Genotyping for SNP- 420C > G in the resistin gene was performed by the polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method. Serum resistin and insulin were measured by immunoassay. Blood glucose levels and lipid profile were measured by enzymatic methods. Homeostasis model of assessment for insulin resistance (HOMA-IR) were calculated.

SUBMITTER: Takhshid MA 

PROVIDER: S-EPMC4419403 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature