Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults.

ABSTRACT:

Background

Acute myeloid leukaemia (AML) with central nervous system (CNS) involvement in adults is uncommon, and studies of this subject are scant.

Methods

We conducted a retrospective study to investigate the clinical aspects, cytogenetic abnormalities, molecular gene mutations and outcomes of adult AML patients with CNS involvement. Three hundred and ninety-five patients with newly diagnosed AML were reviewed.

Results

Twenty (5.1%) patients had CNS involvement, including 7 (1.8%) with initial CNS disease and 4 (1%) who suffered an isolated CNS relapse. The patients with CNS involvement were younger, had higher leukocyte, platelet, and peripheral blast cell counts, FAB M4 morphology, and chromosome translocations involving 11q23 (11q23 abnormalities) more frequently

SUBMITTER: Cheng CL 

PROVIDER: S-EPMC4419415 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature