Common binding by redundant group B Sox proteins is evolutionarily conserved in Drosophila.

ABSTRACT:

Background

Group B Sox proteins are a highly conserved group of transcription factors that act extensively to coordinate nervous system development in higher metazoans while showing both co-expression and functional redundancy across a broad group of taxa. In Drosophila melanogaster, the two group B Sox proteins Dichaete and SoxNeuro show widespread common binding across the genome. While some instances of functional compensation have been observed in Drosophila, the function of common binding and the extent of its evolutionary conservation is not known.

Results

We used DamID-seq to examine the genome-wide binding patterns of Dichaete and SoxNeuro in four species of Drosophila. Through a quantitative comparison of Dichaete binding, we evaluated the rate of binding site turno

SUBMITTER: Carl SH 

PROVIDER: S-EPMC4419465 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature