Interaction between therapeutic interventions for Alzheimer's disease and physiological Aβ clearance mechanisms.

ABSTRACT: Most therapeutic agents are designed to target a molecule or pathway without consideration of the mechanisms involved in the physiological turnover or removal of that target. In light of this and in particular for Alzheimer's disease, a number of therapeutic interventions are presently being developed/investigated which target the amyloid-β peptide (Aβ). However, the literature has not adequately considered which Aβ physiological clearance pathways are necessary and sufficient for the effective action of these therapeutics. In this review, we evaluate the therapeutic strategies targeting Aβ presently in clinical development, discuss the possible interaction of these treatments with pathways that under normal physiological conditions are responsible for the turnover of Aβ and highlight poss

SUBMITTER: Morrone CD 

PROVIDER: S-EPMC4419721 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature