Dataset Information

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.

ABSTRACT:

Background

This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.

Methods

The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.

Results

Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.

Discussion

Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

SUBMITTER: Boccardi M

PROVIDER: S-EPMC4419736 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Publications

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.

Boccardi Marina M Bocchetta Martina M Apostolova Liana G LG Barnes Josephine J Bartzokis George G Corbetta Gabriele G DeCarli Charles C deToledo-Morrell Leyla L Firbank Michael M Ganzola Rossana R Gerritsen Lotte L Henneman Wouter W Killiany Ronald J RJ Malykhin Nikolai N Pasqualetti Patrizio P Pruessner Jens C JC Redolfi Alberto A Robitaille Nicolas N Soininen Hilkka H Tolomeo Daniele D Wang Lei L Watson Craig C Wolf Henrike H Duvernoy Henri H Duchesne Simon S Jack Clifford R CR Frisoni Giovanni B GB Frisoni Giovanni B GB

Alzheimer's & dementia : the journal of the Alzheimer's Association 20140815 2

<h4>Background</h4>This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.<h4>Methods</h4>The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedur ...[more]

PMID: 25130658

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Dataset Information

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.

Background

Methods

Results

Discussion

Publications

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.

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