Increased expression of X-linked genes in mammals is associated with a higher stability of transcripts and an increased ribosome density.

ABSTRACT: Mammalian sex chromosomes evolved from the degeneration of one homolog of a pair of ancestral autosomes, the proto-Y. This resulted in a gene dose imbalance that is believed to be restored (partially or fully) through upregulation of gene expression from the single active X-chromosome in both sexes by a dosage compensatory mechanism. We analyzed multiple genome-wide RNA stability data sets and found significantly longer average half-lives for X-chromosome transcripts than for autosomal transcripts in various human cell lines, both male and female, and in mice. Analysis of ribosome profiling data shows that ribosome density is higher on X-chromosome transcripts than on autosomal transcripts in both humans and mice, suggesting that the higher stability is causally linked to a higher translat

SUBMITTER: Faucillion ML 

PROVIDER: S-EPMC4419800 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature