Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome.

ABSTRACT: Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying more important positions than others and thus being likely to be under stronger selective pressures. However, how positive selection distributes across the different parts of molecular networks is still not fully understood. Here, we inferred positive selection using comparative genomics and population genetics approaches through the comparison of 10 mammalian and 270 human genomes, respectively. In agreement with previous results, we found that genes with lower network centralities are more likely to evolve under positive selection (as inferred from divergence data). Surpri

SUBMITTER: Luisi P 

PROVIDER: S-EPMC4419801 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature