CANDID: a flexible method for prioritizing candidate genes for complex human traits.

ABSTRACT: Genomewide studies and localized candidate gene approaches have become everyday study designs for identifying polymorphisms in genes that influence complex human traits. Yet, in general, the number of significant findings and the need to focus on smaller regions require a prioritization of genes for further study. Some candidate gene identification algorithms have been proposed in recent years to attempt to streamline this prioritization, but many suffer from limitations imposed by the source data or are difficult to use and understand. CANDID is a prioritization algorithm designed to produce impartial, accurate rankings of candidate genes that influence complex human traits. CANDID can use information from publications, protein domain descriptions, cross-species conservation measures, gen

SUBMITTER: Hutz JE 

PROVIDER: S-EPMC4420475 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature