Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy.

ABSTRACT:

Introduction

Several studies have shown that statins suppress the progression of diabetic nephropathy. However, few reports have directly compared the renoprotective effects between potent and conventional statins.

Materials and methods

Patients with diabetic nephropathy, selected as those with a serum creatinine level of 0.9-1.5 mg/dL and simultaneously having either microalbuminuria or positive proteinuria, were randomly assigned to one of three groups: a conventional diet therapy group, a group given 10 mg of pravastatin and a group given 10 mg of atorvastatin. Renal function was evaluated before and after a 12-month period of therapy.

Results

The atorvastatin group had a significant decrease in low-density lipoprotein cholesterol at 3 months and thereafter compare

SUBMITTER: Takazakura A 

PROVIDER: S-EPMC4420568 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature