Intratumoral heterogeneity in a Trp53-null mouse model of human breast cancer.

ABSTRACT:

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Intratumoral heterogeneity correlates with clinical outcome and reflects the cellular complexity and dynamics within a tumor. Such heterogeneity is thought to contribute to radio- and chemoresistance because many treatments may target only certain tumor cell subpopulations. A better understanding of the functional interactions between various subpopulations of cells, therefore, may help in the development of effective cancer treatments. We identified a unique subpopulation of tumor cells expressing mesenchymal-like markers in a Trp53-null mouse model of basal-like breast cancer using fluorescence-activated cell sorting and microarray analysis. Both in vitro and in vivo experiments revealed the existence of cross-talk between these "mesenchymal-like" cells and tumor-initi

SUBMITTER: Zhang M 

PROVIDER: S-EPMC4420701 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature