Residual decline in cognition after adjustment for common neuropathologic conditions.

ABSTRACT:

Objective

Neurodegenerative and cerebrovascular conditions are common in old age and are associated with cognitive decline. However, considerable heterogeneity remains in residual decline (i.e., person-specific trajectories of cognitive decline adjusted for these common neuropathologic conditions). The present study aimed to characterize profiles of residual decline in late life cognition.

Method

Up to 19 waves of longitudinal cognitive data were collected from 876 autopsied participants from 2 ongoing clinical-pathologic cohort studies of aging. Uniform neuropathologic examinations quantified measures of Alzheimer's disease, cerebral infarcts, Lewy body disease, and hippocampal sclerosis. Random effects mixture models characterized latent profiles of residual decline in glo

SUBMITTER: Yu L 

PROVIDER: S-EPMC4420708 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature