Effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton MRS and histologic study.

ABSTRACT: Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy ((1)HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced

SUBMITTER: Auer MK 

PROVIDER: S-EPMC4420876 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature