Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study.

ABSTRACT:

Background

Epidemiologic data on genetic susceptibility to cardiovascular effects of arsenic exposure from drinking water are limited.

Objective

We investigated whether the association between well-water arsenic and cardiovascular disease (CVD) differed by 170 single nucleotide polymorphisms (SNPs) in 17 genes related to arsenic metabolism, oxidative stress, inflammation, and endothelial dysfunction.

Method

We conducted a prospective case-cohort study nested in the Health Effects of Arsenic Longitudinal Study, with a random subcohort of 1,375 subjects and 447 incident fatal and nonfatal cases of CVD. Well-water arsenic was measured in 2000 at baseline. The CVD cases, 56 of which occurred in the subcohort, included 238 coronary heart disease cases, 165 stroke cases, an

SUBMITTER: Wu F 

PROVIDER: S-EPMC4421763 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature