Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.

ABSTRACT:

Background

Understanding of human variation in toxicity to environmental chemicals remains limited, so human health risk assessments still largely rely on a generic 10-fold factor (10½ each for toxicokinetics and toxicodynamics) to account for sensitive individuals or subpopulations.

Objectives

We tested a hypothesis that population-wide in vitro cytotoxicity screening can rapidly inform both the magnitude of and molecular causes for interindividual toxicodynamic variability.

Methods

We used 1,086 lymphoblastoid cell lines from the 1000 Genomes Project, representing nine populations from five continents, to assess variation in cytotoxic response to 179 chemicals. Analysis included assessments of population variation and heritability, and genome-wide association mappin

SUBMITTER: Abdo N 

PROVIDER: S-EPMC4421772 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature